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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TKTL2
All Species:
15.45
Human Site:
S527
Identified Species:
30.91
UniProt:
Q9H0I9
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.36
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9H0I9
NP_115512.3
626
67877
S527
L
E
A
A
D
H
L
S
Q
Q
G
I
S
V
R
Chimpanzee
Pan troglodytes
Q5R1W6
623
67821
K523
L
A
A
A
E
L
L
K
K
E
K
I
N
I
R
Rhesus Macaque
Macaca mulatta
XP_001095403
703
76522
S604
L
A
A
A
D
H
L
S
Q
Q
G
I
S
V
R
Dog
Lupus familis
XP_538204
596
64805
S497
L
A
A
A
E
D
L
S
K
E
D
I
S
I
R
Cat
Felis silvestris
Mouse
Mus musculus
Q9D4D4
627
68429
S528
L
V
A
A
E
E
L
S
Q
Q
G
I
F
I
R
Rat
Rattus norvegicus
P50137
623
67625
K523
L
A
A
A
E
M
L
K
K
E
K
I
G
V
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508404
725
77819
K625
L
A
A
A
D
Q
L
K
K
E
K
I
S
I
R
Chicken
Gallus gallus
XP_414333
627
68436
R523
L
A
A
A
E
Q
L
R
K
E
K
I
F
I
R
Frog
Xenopus laevis
NP_001079885
625
67433
A526
L
A
A
A
D
E
L
A
K
Q
G
I
N
I
R
Zebra Danio
Brachydanio rerio
NP_932336
625
67820
A526
L
A
A
H
D
Q
L
A
K
E
G
V
N
I
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_623357
627
67899
S528
L
K
A
A
D
E
L
S
K
V
G
I
N
I
R
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P23254
680
73787
A577
V
E
A
A
K
T
L
A
A
K
N
I
K
A
R
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
66.1
85.9
75.4
N.A.
80.5
66.1
N.A.
56.8
66.5
72
69.3
N.A.
N.A.
60.1
N.A.
N.A.
Protein Similarity:
100
79.5
86.7
83
N.A.
89.4
79.5
N.A.
69
80.5
84.8
83.3
N.A.
N.A.
75.5
N.A.
N.A.
P-Site Identity:
100
40
93.3
53.3
N.A.
66.6
46.6
N.A.
53.3
40
60
40
N.A.
N.A.
60
N.A.
N.A.
P-Site Similarity:
100
73.3
93.3
80
N.A.
80
66.6
N.A.
73.3
66.6
86.6
80
N.A.
N.A.
86.6
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
25.4
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
43
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
40
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
60
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
67
100
92
0
0
0
25
9
0
0
0
0
9
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
50
9
0
0
0
0
9
0
0
0
0
% D
% Glu:
0
17
0
0
42
25
0
0
0
50
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
17
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
50
0
9
0
0
% G
% His:
0
0
0
9
0
17
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
92
0
67
0
% I
% Lys:
0
9
0
0
9
0
0
25
67
9
34
0
9
0
0
% K
% Leu:
92
0
0
0
0
9
100
0
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
9
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
9
0
34
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
25
0
0
25
34
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
9
0
0
0
0
0
0
100
% R
% Ser:
0
0
0
0
0
0
0
42
0
0
0
0
34
0
0
% S
% Thr:
0
0
0
0
0
9
0
0
0
0
0
0
0
0
0
% T
% Val:
9
9
0
0
0
0
0
0
0
9
0
9
0
25
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _